New Delhi metallo beta-lactamase: What is in a name?

Rapidly emerging novel metallo beta lactamase--New Delhi metallo beta lactamase-1 (NDM-1)--is it a misnomer.

Metallo β-lactamases is the name given to certain enzymes found in gram negative bacteria belonging to Enter-obacteriaceae which confers resistance to all β-lactam antibiotics including carbapenems except monobactams. They belong to Ambler molecular class B and Bush-Jacoby-Medeiros Group 3.1,2 Resistance to carbapenems due to production of metallo β-lactamases in Gram Negative organisms is an i...

New Delhi Metallo-β-Lactamase, Ontario, Canada

To the Editor: The New Delhi metallo-β-lactamase (NDM-1) was fi rst characterized in 2009 from Kleb-siella pneumoniae and Escherichia coli isolated from a patient in Sweden who had received medical care in New Delhi, India (1). Further studies have shown broad dissemination of this β-lactamase gene (bla NDM-1) in India, Pakistan, Bangladesh, and the United Kingdom (2). Additional isolates have ...

Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics

Since the first New Delhi metallo-beta-lactamase (NDM) report in 2009, NDM has spread globally causing various types of infections. NDM-positive organisms produce in vitro resistance phenotypes to carbapenems and many other antimicrobials. It is thus surprising that the literature examining clinical experiences with NDM does not report corresponding poor clinical outcomes. There are many instan...

New Delhi Metallo-Beta-Lactamase (NDM-1)-Producing Klebsiella Pneumoniae Isolated from a Burned Patient

BACKGROUND Infections affecting burn patients are frequently caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacteriaceae species. Infections with these pathogens have become increasingly difficult to treat due to evolving antibiotic resistance mechanisms, including the production of carbapenemases. CASE REPORT The present case report describes the evolution of a burn patient...

Clinical correlates of New Delhi metallo-beta lactamase isolates - a survey of published literature